A wide variety of vegetables and tropical fruits are grown in Santa Isabel. Large swaths of land are dedicated to agriculture, which is one of the main sources of income in the municipality. There are also several manufacturing factories that produce clothing, electrical and electronic equipment, metal products and food products.
Santa Isabel is bordered on the north by the municipality of Coamo, on the south by the Caribbean Sea, on the east by the municipality of Salinas and on the west by Juana Díaz. It is located on the south coast of Puerto Rico in the region known as the southern coastal plain.
Geographically, Santa Isabel is part of the Ponce-Patillas alluvial plain of the southern coastal plain. Its flat and alluvial lands, along with its semi-arid climate, have created some of the most fertile land on the island. The highest elevation in the municipality is the Cerro de las Cuevas, located in the northeast of the Jauca II sector. This peak reaches approximately 984 feet (300 meters) above sea level.
The municipality's hydrological system consists of the Jueyes River, which is the border with Salinas; the Cayures River, which empties into Rincón Bay; the Coamo River, which crosses the municipality from north to southwest and empties into the Caribbean Sea; and the Descalabrado River, which is the border with the municipality of Juana Díaz. To the east of the mouth of the Descalabrado River are Cortada Beach and Cayito Point, and to the southwest is Berbería Key.
The Santa Isabel beach, the Petrona and Aguila points, Jauca Bay and Rincón Bay are located in Santa Isabel and Salinas. Off of Petrona Point are the keys of Caracoles, Cabezazos and Alfeñique and to the east of Jauca Bay is the Los Puercos islet.
Among the natural resources of the municipality is one the four segments of the Aguirre Forest. The Punta Petrona wetlands are located in the western part of the forest, on the Santa Isabel coast. These wetlands consist of salt flats, coastal forests and mangroves. Other mangrove swamps can be found in Jauca Bay and adjacent keys, on Berbería Key and at Cortada Beach. These mangrove stands, along with those of Petrona Point, cover an area of 250 hectares.
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